Double-headed aspirins with bridging groups of different length and molecular structure have been examined for their reactivity with hemoglobin A or S. The compounds constructed are bound in the β-cleft and show a wide range of β-β cross-linking effectiveness. Oxygenation curves of the modified hemoglobins in the presence of inositol hexaphosphate are strikingly modified. Many of the diaspirins also produce substantial changes in the minimum gelling concentration of sickle hemoglobin. These reagents offer possibilities for further enhancement of specificity toward hemoglobin, particularly by taking advatage of stereoselectivities.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Biological Chemistry|
|State||Published - 1981|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology