Structural transitions in DNA driven by external force and torque

Abhijit Sarkar, Jean Francois Léger, Didier Chatenay, John F. Marko

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Abrupt transitions between states of different extensions driven by stretching and twisting were shown by experiments on single DNA molecules. The analysis showed that a statistical-mechanical model was used to globally fit experimental force-extension data over a wide-range of DNA molecule twisting. The mean twist, free energies, and extensions of the five DNA states were obtained experimentally and global force-torque and force-linking number phase diagrams for DNA were predicted.

Original languageEnglish (US)
Article number051903
Pages (from-to)519031-5190310
Number of pages4671280
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Issue number5 I
StatePublished - May 2001

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability


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