Structure-activity relationships for the 9-(pyridin-2'-yl)-aminoacridines

Michael D. Mosher*, Kristi L. Holmes, Katherine S. Frost

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A series of 9-(pyridin-2'-yl)-aminoacridines was prepared and analyzed for their ability to change the thermal denaturation temperature of genomic calf thymus DNA. Development of a QSAR equation indicated that electron withdrawing groups on the pyridine ring promoted the interaction with double stranded DNA.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
Issue number3
StatePublished - Mar 2004


  • Acridine
  • DNA
  • Pyridine
  • QSAR

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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