Structure-activity studies of CTL inhibitory peptides derived from HLA class I molecules

Erich J. Schwartz, Jodi Goldberg, Carol Clayberger, Alan M. Krensky, John H. Griffin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A series of dimeric peptides derived from a conserved HLA Class I hexapeptide sequence have been synthesized and tested for their ability to inhibit T cell-mediated lysis and to disrupt membranes. Structure-activity studies of the C-N/N-C dimer show that activity is especially sensitive to substitution of isoleucine residues. The results further define and delimit the basis for activity by HLA-derived peptides.

Original languageEnglish (US)
Pages (from-to)37-40
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number1
DOIs
StatePublished - Jan 7 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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