TY - JOUR
T1 - Structure and Biology of Type VIII Collagen
AU - Iruela-Arispe, M. Luisa
AU - Chun, Lawrence E.
AU - Helene, E.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - Type VIII collagen was initially characterized as a biosynthetic product of bovine aortic endothelial cells in vitro and thus named Endothelial Collagen(EG). The protein has now been identified in avian and mammalian species as a product seaeted by cultured comeal endothelial cells, keratinocytes, fibroblasts, astrocytoma and other tumor cells, and endothelial cells derived from several classes of blood vessels. In vivo, the distribution of type VIII collagen is restricted to specialized extracellular matrices such as meninges, periosteum, perichondrium, and Descemet's membrane of the cornea. It is also present in the subendothelium of large and small blood vessels and has been localized in capillary-like structures formed by sprouting cultures of endothelial cells. Data firom protein and nucleotide sequencing have identified two distinct chains, termedal(VIII) and ot2(VIII); however, the assembly of these chains in the extracellular space is still poorly understood. Protein extracts firom Descemet's membrane indicate that, in this tissue, type VIII collagen is a heterotrimer. Our understanding of the biological role of type VIII collagen is rather limited. Although type VIII collagen seems to perform a structural role in the Descemet's membrane, its temporally and spatially restricted expression during development suggests an involvement in tissue remodeling and differentiation.
AB - Type VIII collagen was initially characterized as a biosynthetic product of bovine aortic endothelial cells in vitro and thus named Endothelial Collagen(EG). The protein has now been identified in avian and mammalian species as a product seaeted by cultured comeal endothelial cells, keratinocytes, fibroblasts, astrocytoma and other tumor cells, and endothelial cells derived from several classes of blood vessels. In vivo, the distribution of type VIII collagen is restricted to specialized extracellular matrices such as meninges, periosteum, perichondrium, and Descemet's membrane of the cornea. It is also present in the subendothelium of large and small blood vessels and has been localized in capillary-like structures formed by sprouting cultures of endothelial cells. Data firom protein and nucleotide sequencing have identified two distinct chains, termedal(VIII) and ot2(VIII); however, the assembly of these chains in the extracellular space is still poorly understood. Protein extracts firom Descemet's membrane indicate that, in this tissue, type VIII collagen is a heterotrimer. Our understanding of the biological role of type VIII collagen is rather limited. Although type VIII collagen seems to perform a structural role in the Descemet's membrane, its temporally and spatially restricted expression during development suggests an involvement in tissue remodeling and differentiation.
KW - Descemet's membrane
KW - cardiogenesis
KW - collagens
KW - endothelial cells
KW - extracellular matrix
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U2 - 10.4052/tigg.4.188
DO - 10.4052/tigg.4.188
M3 - Article
AN - SCOPUS:85008296901
VL - 4
SP - 188
EP - 199
JO - Trends in Glycoscience and Glycotechnology
JF - Trends in Glycoscience and Glycotechnology
SN - 0915-7352
IS - 16
ER -