Structure and Function of Chromatin Remodelers

Alexis A. Reyes, Ryan D. Marcum, Yuan He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Chromatin remodelers act to regulate multiple cellular processes, such as transcription and DNA repair, by controlling access to genomic DNA. Four families of chromatin remodelers have been identified in yeast, each with non-redundant roles within the cell. There has been a recent surge in structural models of chromatin remodelers in complex with their nucleosomal substrate. These structural studies provide new insight into the mechanism of action for individual chromatin remodelers. In this review, we summarize available data for the structure and mechanism of action of the four chromatin remodeling complex families.

Original languageEnglish (US)
Article number166929
JournalJournal of Molecular Biology
Issue number14
StatePublished - Jul 9 2021


  • CHD
  • INO80
  • ISWI
  • chromatin remodeling

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology


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