Structure and Function of Copper Uptake Transporters

Christopher R. Pope, Adrian G. Flores, Jack H. Kaplan, Vinzenz M Unger*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Owing to their redox and coordination chemistry copper ions play essential roles in cellular function. Research over the past 20 years has shed much light on the biochemistry of copper homeostasis, and the emergence of high-resolution crystal structures for many of the proteins that partake in cellular copper biology have began to provide insight into the molecular mechanisms by which cells handle this important metal. A notable gap in our understanding is related to the process by which cells acquire copper ions. This chapter describes recent progress in the structure determination of cellular copper uptake transporters and how the emerging structural information aids understanding of the molecular mechanisms that govern cellular copper acquisition and distribution.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Membranes
PublisherAcademic Press Inc.
Pages97-112
Number of pages16
DOIs
StatePublished - Jan 1 2012

Publication series

NameCurrent Topics in Membranes
Volume69
ISSN (Print)1063-5823

Keywords

  • Copper transport
  • CTR proteins
  • Electron crystallography
  • EXAFS spectroscopy
  • Mutagenesis
  • Structure-function relationships

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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    Pope, C. R., Flores, A. G., Kaplan, J. H., & Unger, V. M. (2012). Structure and Function of Copper Uptake Transporters. In Current Topics in Membranes (pp. 97-112). (Current Topics in Membranes; Vol. 69). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-394390-3.00004-5