@inbook{de4832c96411486293a1e204b6ac6312,
title = "Structure and Function of Desmosomes",
abstract = "Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic intermediate filament cytoskeleton providing mechanical stability in epithelia and also in several nonepithelial tissues such as cardiac muscle and meninges. They are unique in terms of ultrastructural appearance and molecular composition with cell type-specific variations. The dynamic assembly properties of desmosomes are important prerequisites for the acquisition and maintenance of tissue homeostasis. Disturbance of this equilibrium therefore not only compromises mechanical resilience but also affects many other tissue functions as becomes evident in various experimental scenarios and multiple diseases.",
keywords = "Cadherin, Cancer, Desmocollin, Desmoglein, Desmoplakin, Pemphigus, Plakoglobin, Plakophilin",
author = "Bastian Holth{\"o}fer and Reinhard Windoffer and Sergey Troyanovsky and Leube, {Rudolf E.}",
note = "Funding Information: We wish to thank Dr. Holger Jastrow (this institute) for providing Figs. 3.1B and C , Dr. J{\"u}rgen Kartenbeck (German Cancer Research Center, Heidelberg, Germany) for Figs. 3.6 and 3.7D , Dr. Peter Koch (Baylor College of Medicine, Houston, TX) for contributions to Fig. 3.12 , and Dr. Cord Sunderk{\"o}tter (Clinic and Polyclinic of Dermatology, University M{\"u}nster, Germany) for images presented in Fig. 3.13 . The authors are also grateful for the expert technical help of Ursula Wilhelm. The work was supported by the Deutsche Krebshilfe and the German Research Council.",
year = "2007",
doi = "10.1016/S0074-7696(07)64003-0",
language = "English (US)",
isbn = "0123742633",
series = "International Review of Cytology",
pages = "65--163",
editor = "Kwang Jeon",
booktitle = "A Survey of Cell Biology",
}
