Structure and function of the apical PIKKs in double-strand break repair

Jingfei Xu, Noah Bradley, Yuan He*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Members of the phosphatidylinositol 3ʹ kinase (PI3K)-related kinases (PIKKs) family, including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), ataxia telangiectasia mutated (ATM), ataxia-telangiectasia mutated and Rad3-related (ATR), mammalian target of rapamycin (mTOR), suppressor with morphological effect on genitalia 1 (SMG1), and transformation/transcription domain-associated protein 1 (TRRAP/Tra1), participate in a variety of physiological processes, such as cell-cycle control, metabolism, transcription, replication, and the DNA damage response. In eukaryotic cells, DNA-PKcs, ATM, and ATR-ATRIP are the main sensors and regulators of DNA double-strand break repair. The purpose of this review is to describe recent structures of DNA-PKcs, ATM, and ATR, as well as their functions in activation and phosphorylation in different DNA repair pathways.

Original languageEnglish (US)
Article number102651
JournalCurrent Opinion in Structural Biology
StatePublished - Oct 2023

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology


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