Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase

Keyphrases

• Thymidylate Synthase 100%
• Competitive Inhibitor 100%
• Parallel Optimization 100%
• Novel Scaffolds 66%
• Folate 66%
• Lactobacillus Casei 66%
• Non-substrate 66%
• Computer Program 33%
• 3D Structure 33%
• Novel Inhibitors 33%
• Synthetic Techniques 33%
• Activity Study 33%
• New Inhibitors 33%
• Solid Phase 33%
• Parallel Technique 33%
• Proliferative Disorder 33%
• Molecular Docking 33%
• Combined Structure 33%
• Structure-based Inhibitor Design 33%
• Docking Studies 33%
• Structure-based Screening 33%
• Tight-binding Inhibitors 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Competitive Inhibition 100%
• Thymidylate Synthase 100%
• Lactobacillus casei 66%
• Folic Acid 66%
• Solid 33%
• Software 33%
• Docking (Molecular) 33%