Structure determination of 3β,17-dihydroxy-17α-pregn-5-ene-20-one

Z. Galdecki*, P. Grochulski, Z. Wawrzak, William L. Duax, Phyllis Strong, Albert Segaloff

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review


    The title compound was synthesized as part of an effort to determine the identity of an abnormal steroid metabolite present in the urine of a patient exhibiting pronounced gynecomastia. The X-ray investigation of the synthesized compound showed that the 20-carbonyl of the 17α oriented side chain lies under the D ring, and does not participate in hydrogen bonding in the crystal lattice. This conformation appears to be stable and sufficiently shielded that it is unlikely to make a major contribution to possible protein interactions.

    Original languageEnglish (US)
    Pages (from-to)289-296
    Number of pages8
    Issue number3-4
    StatePublished - 1985

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Endocrinology
    • Pharmacology
    • Clinical Biochemistry
    • Organic Chemistry


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