Structure, function, and regulation of desmosomes

Andrew P. Kowalczyk; Kathleen J. Green

doi:10.1016/B978-0-12-394311-8.00005-4

Structure, function, and regulation of desmosomes

Andrew P. Kowalczyk^*, Kathleen J. Green

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

200 Scopus citations

Abstract

Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.

Original language	English (US)
Title of host publication	The Molecular Biology of Cadherins
Publisher	Elsevier B.V.
Pages	95-118
Number of pages	24
ISBN (Print)	9780123943118
DOIs	https://doi.org/10.1016/B978-0-12-394311-8.00005-4
State	Published - 2013

Publication series

Name	Progress in Molecular Biology and Translational Science
Volume	116
ISSN (Print)	1877-1173

Funding

The authors are grateful to Kowalczyk lab members for helpful comments and advice on this chapter, to Dr. Rebecca Oas for assistance with artwork, and to Sara Stahley for immunofluorescence imaging shown in Fig. 5.1 . A. P. K. is supported by National Institutes of Health R01AR050501 and R01AR048266. K. J. G. is supported by National Institutes of Health RO1 AR041836, R37 AR043380, and R01 CA122151, by a grant from the Leducq Foundation, and by the Joseph L. Mayberry Senior Endowment.

Keywords

Cardiomyopathy
Desmocollin
Desmoglein
Desmoplakin
Epidermis
Pemphigus
Plakoglobin
Plakophilin

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

Access to Document

10.1016/B978-0-12-394311-8.00005-4

Cite this

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abstract = "Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.",

keywords = "Cardiomyopathy, Desmocollin, Desmoglein, Desmoplakin, Epidermis, Pemphigus, Plakoglobin, Plakophilin",

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KW - Plakophilin

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ER -

Structure, function, and regulation of desmosomes

Abstract

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Keywords

ASJC Scopus subject areas

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