Structure-guided design of selective inhibitors of neuronal nitric oxide synthase

Keyphrases

• Structure-based Design 100%
• Selective Inhibitor 100%
• Neuronal Nitric Oxide Synthase (nNOS) 100%
• Neuronal NOS 100%
• Inducible Nitric Oxide Synthase 40%
• Endothelial Nitric Oxide Synthase (eNOS) 40%
• Binding Mode 40%
• Neurodegenerative Diseases 20%
• Nitric Oxide 20%
• Design Project 20%
• Second Messenger 20%
• Selective Inhibition 20%
• Drug Design 20%
• Arginine 20%
• Inhibitor Design 20%
• NOS Inhibitors 20%
• Design Basis 20%
• Structure-guided 20%
• Excellent Selectivity 20%
• Inhibitory Potency 20%
• Isoform Selectivity 20%
• Citrulline 20%
• Enzyme Selectivity 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Neuronal Nitric Oxide Synthase 100%
• Compounds of Lead 50%
• Drug Development 50%
• Nitric Oxide 50%
• Nitric Oxide Synthase 50%
• Degenerative Disease 50%
• Arginine 50%
• Citrulline 50%
• Isoenzyme 50%

Biochemistry, Genetics and Molecular Biology

• Nitric Oxide Synthase 100%
• Isoform 66%
• Crystal Structure 33%
• Second Messenger System 33%
• Nitric Oxide 33%
• Isozyme 33%
• Arginine 33%
• Citrulline 33%