Structure of 6-methyl-3,20-dioxo-4,6-pregnadien-17α-yl acetate, C 24 H 32 O 4

Zdzislaw Wawrzak*, Pawel Grochulski, Zdzislaw Galdecki, Jane F. Griffin, Phyllis D. Strong, William L. Duax

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    The X-ray structure of 6-methyl-3,20-dioxo-4,6-pregnadien-17 α-yl acetate is reported. The crystals are monoclinic, space group P2 1 , Z=4, a=28.955(7), b=6.597(2), c=11.064(3) Å, /gb=90.80(2) °. The two crystallographically independent molecules have very similar overall geometries. The A rings have intermediate sofa-half-chair conformations and are bent relative to the steroid skeleton. The conformation of the 17 β-progesterone side chain is stabilized by the 17 α-ester substituent; the C(16)-C(17)-C(20)-O(20) torsion angle is -19.4(6) and -20.6(7)°.

    Original languageEnglish (US)
    Pages (from-to)65-69
    Number of pages5
    JournalJournal of Crystallographic and Spectroscopic Research
    Volume22
    Issue number1
    DOIs
    StatePublished - Feb 1 1992

    ASJC Scopus subject areas

    • Structural Biology
    • Condensed Matter Physics
    • Spectroscopy

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