Structure of Escherichia coli ribonucleotide reductase R2 in space group P6122

Monika Sommerhalter, Lana Saleh, J. Martin Bollinger, Amy C. Rosenzweig*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A new crystal form of wild-type ribonucleotide reductase R2 from Escherichia coli was obtained. Crystals grow in space group P6122 with one R2 monomer in the asymmetric unit. A twofold crystallographic symmetry axis generates the physiological dimeric form of R2. Co-crystallization with CoCl2 or MnCl2 results in full occupancy of the dinuclear metal site. The structure of the MnII-loaded form was determined to 2.6 Å resolution by molecular replacement. The crystallization conditions, backbone conformation, crystal-packing interactions and metal centers are compared with those of previously determined crystal forms.

Original languageEnglish (US)
Pages (from-to)1649-1654
Number of pages6
JournalActa Crystallographica Section D: Biological Crystallography
Issue number12
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Structural Biology


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