Structure of HLA molecules and immunosuppressive effects of HLA derived peptides

Alan M. Krensky*, Carol Clayberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these molecules, there is also evolutionary pressure to maintain the relatively monomorphic portions of these molecules. Drs. Krensky and Clayberger have found that synthetic peptides corresponding to linear sequences of HLA molecules have immunomodulatory effects both in vitro and in vivo. In this paper, they review the structure of HLA molecules and their studies of HLA derived peptides as novel immunotherapeutics. Members of the heat shock protein 70 family are implicated in the HLA derived peptide immunosuppressive pathway.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalInternational Reviews of Immunology
Issue number3
StatePublished - 1996


  • Human leukocyte antigens (HLA)
  • Immunotherapy
  • Peptides
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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