Structure of HLA molecules and immunosuppressive effects of HLA derived peptides

Alan M. Krensky*, Carol Clayberger

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Elucidation of the structure of MHC molecules has provided profound new insights into their function in antigen presentation. In addition, structural studies have implicated certain regions of MHC molecules in specific functions. Although much of MHC biology has concentrated on the extensive polymorphism among these molecules, there is also evolutionary pressure to maintain the relatively monomorphic portions of these molecules. Drs. Krensky and Clayberger have found that synthetic peptides corresponding to linear sequences of HLA molecules have immunomodulatory effects both in vitro and in vivo. In this paper, they review the structure of HLA molecules and their studies of HLA derived peptides as novel immunotherapeutics. Members of the heat shock protein 70 family are implicated in the HLA derived peptide immunosuppressive pathway.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalInternational Reviews of Immunology
Volume13
Issue number3
DOIs
StatePublished - Jan 1 1996

Keywords

  • Human leukocyte antigens (HLA)
  • Immunotherapy
  • Peptides
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Structure of HLA molecules and immunosuppressive effects of HLA derived peptides'. Together they form a unique fingerprint.

  • Cite this