Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site

Xiaolin Wen, Jens C. Krause, George P. Leser, Reagan G. Cox, Robert A. Lamb, John V. Williams, James E. Crowe, Theodore S. Jardetzky*

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

Original languageEnglish (US)
Pages (from-to)461-463
Number of pages3
JournalNature Structural and Molecular Biology
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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