Structure of the lysozyme from bacteriophage T4: An electron density map at 2.4 Å resolution

S. J. Remington*, W. F. Anderson, J. Owen, L. F Ten Eyck, C. T. Grainger, B. W. Matthews

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

The three-dimensional structure of the lysozyme from bacteriophage T4 has been determined from a 2.4 Å resolution electron density map. The map, determined using isomorphous replacement and anomalous scattering differences from platinum and mercury-substituted crystals, reveals the approximate conformation of the molecule unambiguously. Details of the structure determination are presented and the conformation of the molecule is described in detail. The observed properties of those mutant lysozymes for which the changes in the amino acid sequence have been determined are discussed in the light of the three-dimensional structure. In most cases the behavior of the mutant lysozymes can be easily rationalized, but there are a few instances where this is not so.

Original languageEnglish (US)
Pages (from-to)81-98
Number of pages18
JournalJournal of Molecular Biology
Volume118
Issue number1
DOIs
StatePublished - Jan 5 1978

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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