Structure-Reactivity-Property Relationships in Covalent Adaptable Networks

Vivian Zhang; Boyeong Kang; Joseph V. Accardo; Julia A. Kalow

doi:10.1021/jacs.2c08104

Structure-Reactivity-Property Relationships in Covalent Adaptable Networks

Vivian Zhang, Boyeong Kang, Joseph V. Accardo, Julia A. Kalow^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Polymer networks built out of dynamic covalent bonds offer the potential to translate the control and tunability of chemical reactions to macroscopic physical properties. Under conditions at which these reactions occur, the topology of covalent adaptable networks (CANs) can rearrange, meaning that they can flow, self-heal, be remolded, and respond to stimuli. Materials with these properties are necessary to fields ranging from sustainability to tissue engineering; thus the conditions and time scale of network rearrangement must be compatible with the intended use. The mechanical properties of CANs are based on the thermodynamics and kinetics of their constituent bonds. Therefore, strategies are needed that connect the molecular and macroscopic worlds. In this Perspective, we analyze structure-reactivity-property relationships for several classes of CANs, illustrating both general design principles and the predictive potential of linear free energy relationships (LFERs) applied to CANs. We discuss opportunities in the field to develop quantitative structure-reactivity-property relationships and open challenges.

Original language	English (US)
Pages (from-to)	22358-22377
Number of pages	20
Journal	Journal of the American Chemical Society
Volume	144
Issue number	49
DOIs	https://doi.org/10.1021/jacs.2c08104
State	Published - Dec 14 2022

Funding

V.Z. and B.K. were supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R01GM132677. V.Z. was partially supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Number F30DK129002. J.V.A. was supported by the NSF Center for the Chemistry of Molecularly Optimized Networks (MONET), CHE-2116298. This content is solely the responsibility of the authors and does not necessarily represent the official views of the National Science Foundation or National Institutes of Health. J.A.K. is supported by a Sloan Research Fellowship and a Dreyfus Teacher-Scholar Award.

ASJC Scopus subject areas

General Chemistry
Biochemistry
Catalysis
Colloid and Surface Chemistry

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10.1021/jacs.2c08104

Cite this

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title = "Structure-Reactivity-Property Relationships in Covalent Adaptable Networks",

abstract = "Polymer networks built out of dynamic covalent bonds offer the potential to translate the control and tunability of chemical reactions to macroscopic physical properties. Under conditions at which these reactions occur, the topology of covalent adaptable networks (CANs) can rearrange, meaning that they can flow, self-heal, be remolded, and respond to stimuli. Materials with these properties are necessary to fields ranging from sustainability to tissue engineering; thus the conditions and time scale of network rearrangement must be compatible with the intended use. The mechanical properties of CANs are based on the thermodynamics and kinetics of their constituent bonds. Therefore, strategies are needed that connect the molecular and macroscopic worlds. In this Perspective, we analyze structure-reactivity-property relationships for several classes of CANs, illustrating both general design principles and the predictive potential of linear free energy relationships (LFERs) applied to CANs. We discuss opportunities in the field to develop quantitative structure-reactivity-property relationships and open challenges.",

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AU - Zhang, Vivian

AU - Kang, Boyeong

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Y1 - 2022/12/14

N2 - Polymer networks built out of dynamic covalent bonds offer the potential to translate the control and tunability of chemical reactions to macroscopic physical properties. Under conditions at which these reactions occur, the topology of covalent adaptable networks (CANs) can rearrange, meaning that they can flow, self-heal, be remolded, and respond to stimuli. Materials with these properties are necessary to fields ranging from sustainability to tissue engineering; thus the conditions and time scale of network rearrangement must be compatible with the intended use. The mechanical properties of CANs are based on the thermodynamics and kinetics of their constituent bonds. Therefore, strategies are needed that connect the molecular and macroscopic worlds. In this Perspective, we analyze structure-reactivity-property relationships for several classes of CANs, illustrating both general design principles and the predictive potential of linear free energy relationships (LFERs) applied to CANs. We discuss opportunities in the field to develop quantitative structure-reactivity-property relationships and open challenges.

AB - Polymer networks built out of dynamic covalent bonds offer the potential to translate the control and tunability of chemical reactions to macroscopic physical properties. Under conditions at which these reactions occur, the topology of covalent adaptable networks (CANs) can rearrange, meaning that they can flow, self-heal, be remolded, and respond to stimuli. Materials with these properties are necessary to fields ranging from sustainability to tissue engineering; thus the conditions and time scale of network rearrangement must be compatible with the intended use. The mechanical properties of CANs are based on the thermodynamics and kinetics of their constituent bonds. Therefore, strategies are needed that connect the molecular and macroscopic worlds. In this Perspective, we analyze structure-reactivity-property relationships for several classes of CANs, illustrating both general design principles and the predictive potential of linear free energy relationships (LFERs) applied to CANs. We discuss opportunities in the field to develop quantitative structure-reactivity-property relationships and open challenges.

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Structure-Reactivity-Property Relationships in Covalent Adaptable Networks

Abstract

Funding

ASJC Scopus subject areas

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