Structured interference optical coherence tomography

Ji Yi; Qing Wei; Hao F. Zhang; Vadim Backman

doi:10.1364/OL.37.003048

Structured interference optical coherence tomography

Ji Yi^*, Qing Wei, Hao F. Zhang, Vadim Backman

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We developed a structured interference optical coherence tomography (SIOCT) to enhance the lateral resolution beyond the diffraction limit. A sinusoidal pattern is created on the interferometric beam with the reference intensity temporally modulated. In the Fourier domain, the high spatial frequencies are shifted into the detectable range, which enhances the lateral resolution beyond the diffraction limit by a factor of 2. The lateral resolution of SIOCT was characterized in our study as ∼5.5 μm, surpassing the diffraction limit ∼9.6 μm as in conventional Fourier-domain optical coherence tomography. SIOCT was demonstrated on phantoms and ex vivo adipose tissues.

Original language	English (US)
Pages (from-to)	3048-3050
Number of pages	3
Journal	Optics Letters
Volume	37
Issue number	15
DOIs	https://doi.org/10.1364/OL.37.003048
State	Published - Aug 1 2012

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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AU - Wei, Qing

AU - Zhang, Hao F.

AU - Backman, Vadim

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N2 - We developed a structured interference optical coherence tomography (SIOCT) to enhance the lateral resolution beyond the diffraction limit. A sinusoidal pattern is created on the interferometric beam with the reference intensity temporally modulated. In the Fourier domain, the high spatial frequencies are shifted into the detectable range, which enhances the lateral resolution beyond the diffraction limit by a factor of 2. The lateral resolution of SIOCT was characterized in our study as ∼5.5 μm, surpassing the diffraction limit ∼9.6 μm as in conventional Fourier-domain optical coherence tomography. SIOCT was demonstrated on phantoms and ex vivo adipose tissues.

AB - We developed a structured interference optical coherence tomography (SIOCT) to enhance the lateral resolution beyond the diffraction limit. A sinusoidal pattern is created on the interferometric beam with the reference intensity temporally modulated. In the Fourier domain, the high spatial frequencies are shifted into the detectable range, which enhances the lateral resolution beyond the diffraction limit by a factor of 2. The lateral resolution of SIOCT was characterized in our study as ∼5.5 μm, surpassing the diffraction limit ∼9.6 μm as in conventional Fourier-domain optical coherence tomography. SIOCT was demonstrated on phantoms and ex vivo adipose tissues.

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Structured interference optical coherence tomography

Abstract

ASJC Scopus subject areas

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