TY - JOUR
T1 - Structured treatment interruptions (STIs) in HIV-1 infected pediatric populations increases interferon gamma production and reduces viremia
AU - Borkowsky, William
AU - Yogev, Ram
AU - Muresan, Petronella
AU - McFarland, Elizabeth
AU - Frenkel, Lisa
AU - Fenton, Terry
AU - Capparelli, Edmond
AU - Moye, Jack
AU - Harding, Paul
AU - Ellis, Nina
AU - Heckman, Barbara
AU - Kraimer, Joyce
N1 - Funding Information:
This study was support by the NIH NIAID and NICHD through the pediatric AIDS Clinical Trials Program. Several of the participating sites have also relied on support from their General Clinical Research Centers, National Centers for Research Resources, NIH (M01 RR00069 and RR00096). The inactivated whole HIV was supplied by Drs. Larry Arthur and Jeffrey Lifson (NCI, NIH). The vaccinia vectors were supplied by supplied by Dr. James Tartaglia (Sanofi Pasteur) and are available at the AIDS Reagent Program. The study would not have been possible without the courage and effort of the HIV-infected study participants. The manuscript which provides the actual data is in press in AIDS Research and Human Retroviruses (volume 24, pages 401–411).
PY - 2008/6/6
Y1 - 2008/6/6
N2 - We assessed the effect of progressively longer antiretroviral structured treatment interruptions (STIs) starting with 3 days, increasing by 2 days in length each cycle on HIV-specific immune responses. As well, we correlated these responses with control of HIV viremia. Eight individuals became viremic and reached cycle 13 with an STI of ≥27 days. HIV-specific gamma-interferon production to inactivated HIV and vaccinia vectors expressing gag, env, nef, and pol increased (>10-fold) in six of eight subjects. Median plasma RNA levels peaked @ cycle 7 and declined to levels <104 cp/ml after cycle 10. In a subset of five who reached cycle 17, HIV-specific IFN-gamma frequencies increased from cycle 8 to cycle 17 with evidence of improved virologic control over comparable periods off antiretroviral therapy. This allowed us to conclude that exposure to autologous virus increased HIV-specific immune responses and decreased HIV RNA were seen in those who have had >13 interruptions, with STI intervals that exceeded 27 days.
AB - We assessed the effect of progressively longer antiretroviral structured treatment interruptions (STIs) starting with 3 days, increasing by 2 days in length each cycle on HIV-specific immune responses. As well, we correlated these responses with control of HIV viremia. Eight individuals became viremic and reached cycle 13 with an STI of ≥27 days. HIV-specific gamma-interferon production to inactivated HIV and vaccinia vectors expressing gag, env, nef, and pol increased (>10-fold) in six of eight subjects. Median plasma RNA levels peaked @ cycle 7 and declined to levels <104 cp/ml after cycle 10. In a subset of five who reached cycle 17, HIV-specific IFN-gamma frequencies increased from cycle 8 to cycle 17 with evidence of improved virologic control over comparable periods off antiretroviral therapy. This allowed us to conclude that exposure to autologous virus increased HIV-specific immune responses and decreased HIV RNA were seen in those who have had >13 interruptions, with STI intervals that exceeded 27 days.
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U2 - 10.1016/j.vaccine.2007.12.017
DO - 10.1016/j.vaccine.2007.12.017
M3 - Article
C2 - 18472197
AN - SCOPUS:44649188130
SN - 0264-410X
VL - 26
SP - 3086
EP - 3089
JO - Vaccine
JF - Vaccine
IS - 24
ER -
