Structure/function studies of arsenite oxidoreductase and xanthine oxidase

Palanichamy Manikandan, Paul Ellis, Peter Kuhn, Eun Young Choi, Brian Hoffman, Russ Hille*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The recently solved X-ray crystal structure of the molybdenum-containing arsenite oxidoreductase from Alcaligenes faecalis, is discussed, keeping in view the known mechanistic and spectroscopic information regarding the protein in a structural context. In addition, recent mechanistic studies of xanthine oxidase are covered, with the conclusion that the reaction mechanism is initiated by nucleophilic attack of a Mo-OH group on substrate.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalIndian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry
Issue number1
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry


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