Studies of coagulation and platelet functions in heparin-free hemodialysis

P. Ivanovich, C. G. Xu, H. C. Kwaan, S. Hathiwala

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Hematologic and coagulation studies were carried out during 12 heparin-free hemodialyses in 9 maintenance hemodialysis patients. Treatment employed a C-DAK 4000 cellulose acetate membrane hemodialyzer. Both hemodialyzer and blood tubing were periodically flushed with physiologic saline. No significant clotting of the hemodialyzers was encountered in uneventful dialyses. Platelet counts, platelet aggregation with ADP and epinephrine, antithrombin III and fibrinogen/fibrin degradation products were not significantly changed compared with pre-dialysis values. Fibrino-peptide A levels, elevated pre-treatment, demonstrated additional rise during dialysis. These findings support clinical experience that this anticoagulation-free method can be used safely and effectively to dialyze patients at risk for bleeding.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
Issue number2
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Nephrology


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