Studies of retinopathy and the plasma co-factor of platelet hyperaggregation in Type 1 (insulin-dependent) diabetic children

R. D. Levin*, H. C. Kwaan, J. G. Dobbie, C. L. Fetkenhour, H. S. Traisman, C. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Only one out of 73 children with young-onset Type 1 (insulin-dependent) diabetes for less than 10 years had retinopathy detectable with fluorescein retinal angiography. Although these fluorescent studies were normal, retinal abnormalities were detected in 19 out of 53 patients by electro-retinography and in four out of 28 patients by the 100-hue colour test. We were unable to confirm recent reports indicating that most Type 1 diabetic patients have retinopathy detectable by fluorescein angiography. The diabetic plasma co-factor induces normal platelets to hyperaggregate in vitro. Plasma co-factor activities in adult diabetic patients have previously been shown to correlate with the degree of hyperaggregation, although in general, only those patients with severe retinopathy or nephropathy have high plasma activities. The plasma activities of 192 Type 1 diabetic patients were significantly higher than those of normal subjects (p< 0.01). Of ten children with markedly elevated activities, nine did not have retinopathy.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
Issue number6
StatePublished - Jun 1982


  • Type 1 diabetes
  • fluorescein retinal angiography
  • plasma co-factor
  • platelets

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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