Abstract
Peritoneal macrophages (mφ), activated by Bacillus Callmette-Guerin (BCG) or elicited by thioglycollate broth in vivo in C57BL/6J mice, were compared with regard to their ability to mediate antibody-dependent cellular cytotoxicity (ADCC). The BCG-activated mφ had several times higher ADCC activity than did the TG-mφ against erythroid targets. When human and murine tumor cells were employed as targets in the ADCC assay, the BCG-mφ lysed each of six separate target lines considerably, while the TG-mφ had little and, occasionally no, lytic activity against the six targets. Although Fc-dependent and -independent phagocytosis of the erythroid targets by the TG-mφ exceeded that by the BCG-mφ, this rapid and extensive phagocytosis did not account soley for the decreased lysis of the erythroid targets by the TG-mφ. The results indicate that BCG-activated peritoneal mφ, in comparision with TG-elicited inflammatory mφ, are potent effectors of ADCC against both erythroid and neoplastic target cells.
Original language | English (US) |
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Pages (from-to) | 51-61 |
Number of pages | 11 |
Journal | Cellular Immunology |
Volume | 57 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1981 |
Funding
’ Supported in part by USPHS Grants CA-23354, CA-16784, CA-14049, and CA-14236. Hillel S. Koren is a recipient of a Research Career Development Award from the National Cancer Institute CA-00581.
ASJC Scopus subject areas
- Immunology