Studies on the mechanism of clinical tolerance in solar urticaria

T. M. KEAHEY*, R. M. LAVKER, KAYSH KAIDBEY, P. C. ATKINS, B. ZWEIMAN

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Tolerance to artificial ultraviolet radiation (UVR) was induced in three patients with solar urticaria by administering graded whole body exposures to long‐wave ultraviolet radiation (UV‐A, 320–400 nm) in a phototherapy cabinet. Plasma histamine levels, mast cell ultrastructure and cutaneous responses to intradermally injected codeine and histamine were examined before and after the induction of tolerance. No evidence of serum complement activation could be demonstrated following exposure of serum samples to UVR in vitro. These studies suggest that the state of tolerance is due neither to mediator (histamine) depletion nor to a systemic effect induced by UV‐A but may be due to an increase in the mast cell degranulation threshold.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalBritish Journal of Dermatology
Volume110
Issue number3
DOIs
StatePublished - Mar 1984

ASJC Scopus subject areas

  • Dermatology

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