Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

M. M.G. Saldívar-Ramírez; C. G. Sánchez-Torres; D. A. Cortés-Hernández; J. C. Escobedo-Bocardo; J. M. Almanza-Robles; A. Larson; P. J. Reséndiz-Hernández; I. O. Acuña-Gutiérrez

doi:10.1007/s10856-014-5187-3

Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

M. M.G. Saldívar-Ramírez^*, C. G. Sánchez-Torres, D. A. Cortés-Hernández, J. C. Escobedo-Bocardo, J. M. Almanza-Robles, A. Larson, P. J. Reséndiz-Hernández, I. O. Acuña-Gutiérrez

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Magnetic materials, which have the potential for application in heating therapy by hyperthermia, were prepared. This alternative treatment is used to eliminate cancer cells. Magnetite, magnesium–calcium ferrites and manganese–calcium ferrites were synthesized by sol–gel method followed by heat treatment at different temperatures for 30 min in air. Materials with superparamagnetic behavior and nanometric sizes were obtained in all the cases. Thus, these nanopowders may be suitable for their use in human tissue. The average sizes were 14 nm for magnetite, 10 nm for both Mg_0.4Ca_0.6Fe₂O₄ and Mg_0.6Ca_0.4Fe₂O₄ and 11 nm for Mn_0.2Ca_0.8Fe₂O₄. Taking into account that the Mg_0.4Ca_0.6Fe₂O₄ and Mg_0.6Ca_0.4Fe₂O₄ treated at 350 °C showed the lower coercivity values, these nanoparticles were selected for heating tests and cell viability. Heating curves of Mg_0.4Ca_0.6Fe₂O₄ subjected to a magnetic field of 195 kHz and 10 kA/m exhibited a temperature increase up to 45 °C in 15 min. A high human osteosarcoma cell viability of 90–99.5 % was displayed. The human osteosarcoma cell with magnesium–calcium ferrites exposed to a magnetic field revealed a death cell higher than 80 % in all the cases.

Original language	English (US)
Pages (from-to)	2229-2236
Number of pages	8
Journal	Journal of Materials Science: Materials in Medicine
Volume	25
Issue number	10
DOIs	https://doi.org/10.1007/s10856-014-5187-3
State	Published - Sep 20 2014

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1007/s10856-014-5187-3

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Saldívar-Ramírez, M. M. G., Sánchez-Torres, C. G., Cortés-Hernández, D. A., Escobedo-Bocardo, J. C., Almanza-Robles, J. M., Larson, A., Reséndiz-Hernández, P. J., & Acuña-Gutiérrez, I. O. (2014). Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia. Journal of Materials Science: Materials in Medicine, 25(10), 2229-2236. https://doi.org/10.1007/s10856-014-5187-3

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title = "Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia",

abstract = "Magnetic materials, which have the potential for application in heating therapy by hyperthermia, were prepared. This alternative treatment is used to eliminate cancer cells. Magnetite, magnesium–calcium ferrites and manganese–calcium ferrites were synthesized by sol–gel method followed by heat treatment at different temperatures for 30 min in air. Materials with superparamagnetic behavior and nanometric sizes were obtained in all the cases. Thus, these nanopowders may be suitable for their use in human tissue. The average sizes were 14 nm for magnetite, 10 nm for both Mg0.4Ca0.6Fe2O4 and Mg0.6Ca0.4Fe2O4 and 11 nm for Mn0.2Ca0.8Fe2O4. Taking into account that the Mg0.4Ca0.6Fe2O4 and Mg0.6Ca0.4Fe2O4 treated at 350 °C showed the lower coercivity values, these nanoparticles were selected for heating tests and cell viability. Heating curves of Mg0.4Ca0.6Fe2O4 subjected to a magnetic field of 195 kHz and 10 kA/m exhibited a temperature increase up to 45 °C in 15 min. A high human osteosarcoma cell viability of 90–99.5 % was displayed. The human osteosarcoma cell with magnesium–calcium ferrites exposed to a magnetic field revealed a death cell higher than 80 % in all the cases.",

author = "Sald{\'i}var-Ram{\'i}rez, {M. M.G.} and S{\'a}nchez-Torres, {C. G.} and Cort{\'e}s-Hern{\'a}ndez, {D. A.} and Escobedo-Bocardo, {J. C.} and Almanza-Robles, {J. M.} and A. Larson and Res{\'e}ndiz-Hern{\'a}ndez, {P. J.} and Acu{\~n}a-Guti{\'e}rrez, {I. O.}",

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Saldívar-Ramírez, MMG, Sánchez-Torres, CG, Cortés-Hernández, DA, Escobedo-Bocardo, JC, Almanza-Robles, JM, Larson, A, Reséndiz-Hernández, PJ & Acuña-Gutiérrez, IO 2014, 'Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia', Journal of Materials Science: Materials in Medicine, vol. 25, no. 10, pp. 2229-2236. https://doi.org/10.1007/s10856-014-5187-3

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T1 - Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

AU - Saldívar-Ramírez, M. M.G.

AU - Sánchez-Torres, C. G.

AU - Cortés-Hernández, D. A.

AU - Escobedo-Bocardo, J. C.

AU - Almanza-Robles, J. M.

AU - Larson, A.

AU - Reséndiz-Hernández, P. J.

AU - Acuña-Gutiérrez, I. O.

PY - 2014/9/20

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AB - Magnetic materials, which have the potential for application in heating therapy by hyperthermia, were prepared. This alternative treatment is used to eliminate cancer cells. Magnetite, magnesium–calcium ferrites and manganese–calcium ferrites were synthesized by sol–gel method followed by heat treatment at different temperatures for 30 min in air. Materials with superparamagnetic behavior and nanometric sizes were obtained in all the cases. Thus, these nanopowders may be suitable for their use in human tissue. The average sizes were 14 nm for magnetite, 10 nm for both Mg0.4Ca0.6Fe2O4 and Mg0.6Ca0.4Fe2O4 and 11 nm for Mn0.2Ca0.8Fe2O4. Taking into account that the Mg0.4Ca0.6Fe2O4 and Mg0.6Ca0.4Fe2O4 treated at 350 °C showed the lower coercivity values, these nanoparticles were selected for heating tests and cell viability. Heating curves of Mg0.4Ca0.6Fe2O4 subjected to a magnetic field of 195 kHz and 10 kA/m exhibited a temperature increase up to 45 °C in 15 min. A high human osteosarcoma cell viability of 90–99.5 % was displayed. The human osteosarcoma cell with magnesium–calcium ferrites exposed to a magnetic field revealed a death cell higher than 80 % in all the cases.

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Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

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