TY - JOUR
T1 - Study Protocol
T2 - Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury
AU - Saiote, Catarina
AU - Sutter, Ellen
AU - Xenopoulos-Oddsson, Annette
AU - Rao, Raghavendra
AU - Georgieff, Michael
AU - Rudser, Kyle
AU - Peyton, Colleen
AU - Dean, Douglas
AU - McAdams, Ryan M.
AU - Gillick, Bernadette
N1 - Funding Information:
Grant Support: This work was supported in part by a Promotion of Doctoral Studies I Scholarship from the Foundation for Physical Therapy Research and by the Shepherd Family Trust.
Funding Information:
Grant Support: This work is supported by the National Institute of Child Health and Human Development/National Institute of Neurological Disorders and Stroke (7R01HD098202-02).
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Purpose: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. Methods: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. Discussion: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.
AB - Purpose: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. Methods: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. Discussion: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.
KW - cerebral palsy
KW - infant
KW - magnetic resonance imaging
KW - movement assessment
KW - perinatal stroke
KW - transcranial magnetic stimulation
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U2 - 10.1097/PEP.0000000000000886
DO - 10.1097/PEP.0000000000000886
M3 - Article
C2 - 35385465
AN - SCOPUS:85127631266
SN - 0898-5669
VL - 34
SP - 268
EP - 276
JO - Pediatric Physical Therapy
JF - Pediatric Physical Therapy
IS - 2
ER -