Sub-micron patterning on polymer films for protein arrays

Karen L. Christman, Michael V. Requa, Vanessa D. Enriquez-Rios, Paula Mendes, J. Fraser Stoddart, Kimberly L. Turner, Heather D. Maynard*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Patterning proteins at the sub-micron and nanoscale has many uses, including fabrication of protein arrays for diagnostic and sensor applications. Many groups have reported micron scale protein patterns using photolithography; however, smaller scales have not been realized. In this study, we demonstrate sub-micron protein patterns using photolithography. Patterning is achieved by chemical transformation of pH-reactive polymer films. Site-specific immobilization of streptavidin within a protein resistant background is demonstrated. This methodology could be utilized for the development of high density proteins arrays for biotechnology applications.

Original languageEnglish (US)
Title of host publicationNanoparticles and Nanostructures in Sensors and Catalysis
PublisherMaterials Research Society
Number of pages5
ISBN (Print)1558998543, 9781558998544
StatePublished - 2005
Event2005 MRS Fall Meeting - Boston, MA, United States
Duration: Nov 28 2005Dec 2 2005

Publication series

NameMaterials Research Society Symposium Proceedings
ISSN (Print)0272-9172


Other2005 MRS Fall Meeting
Country/TerritoryUnited States
CityBoston, MA

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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