Subacute sensory neuronopathy secondary to dorsal root ganglionitis in primary Sjögren's syndrome

K. Malinow, G. D. Yannakakis, S. M. Glusman, D. W. Edlow, J. Griffin, A. Pestronk, D. L. Powell, R. Ramsey‐Goldman, B. H. Eidelman, T. A. Medsger, E. L. Alexander*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Sensory neuropathies, particularly trigeminal neuropathy, have been recognized as neurological complications of Sjögren's syndrome, but the pathogenesis has not been established. We describe a woman with primary Sjögren's syndrome who developed a progressive debilitating subacute sensory neuronopathy. Results of electrophysiological studies were consistent with involvement of the trigeminal and dorsal root ganglia. A thoracic dorsal root ganglion biopsy showed lymphocytic infiltration and degeneration of ganglion cells. We believe that this is the first description of biopsy‐documented dorsal root ganglionitis in a subacute sensory neuronopathy associated with Sjögren's syndrome and that the finding suggests an immunopathogenic basis.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalAnnals of neurology
Volume20
Issue number4
DOIs
StatePublished - Oct 1986

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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