Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat

Jesse J. Liu; Jeffrey S. Raskin; Robin McFarlane; Ravi Samatham; Justin S. Cetas

doi:10.1007/978-3-030-04615-6_14

Subarachnoid hemorrhage pattern predicts acute cerebral blood flow response in the rat

Jesse J. Liu, Jeffrey S. Raskin, Robin McFarlane, Ravi Samatham, Justin S. Cetas^*

^*Corresponding author for this work

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.

Original language	English (US)
Title of host publication	Acta Neurochirurgica, Supplementum
Publisher	Springer-Verlag Wien
Pages	83-89
Number of pages	7
DOIs	https://doi.org/10.1007/978-3-030-04615-6_14
State	Published - 2020

Publication series

Name	Acta Neurochirurgica, Supplementum
Volume	127
ISSN (Print)	0065-1419
ISSN (Electronic)	2197-8395

Funding

Acknowledgments This work was supported by the Veterans Administration Merit # 5I01 BX001659-03 from the US Department of Veterans Affairs. This work was supported by the Veterans Administration Merit # 5I01 BX001659-03 from the US Department of Veterans Affairs.

Keywords

14,15-EET
20-HETE
Cortical spreading depolarization
Early brain injury
P450 eicosanoids
Stroke glymphatic
Subarachnoid hemorrhage

ASJC Scopus subject areas

Surgery
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-04615-6_14

Cite this

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abstract = "There is considerable variability in the presentation of patients with acute subarachnoid hemorrhage (aSAH). Evidence suggests that a thick, diffuse clot better predicts the development of delayed cerebral ischemia and poor outcomes. In a rodent model of acute SAH, we directly measured the effects of the volume of blood injected versus the pattern of distribution of hemorrhage in the subarachnoid space on markers of early brain injury, namely, cerebral blood flow (CBF), cerebrospinal fluid (CSF) concentrations of P450 eicosanoids and catecholamines, and cortical spreading depolarizations (CSDs). There is a significant decrease in CBF, an increase in CSF biomarkers, and a trend toward increasing frequency and severity of CSDs when grouped by severity of hemorrhage but not by volume of blood injected. In severe hemorrhage grade animals, there was a progressive decrease in CBF after successive CSD events. These results suggest that the pattern of SAH (thick diffuse clots) correlates with the “clinical” severity of SAH.",

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