TY - JOUR
T1 - Subcortical alignment precision in patients with schizophrenia
AU - Anticevic, Alan
AU - Repovs, Grega
AU - Van Snellenberg, Jared X.
AU - Csernansky, John G.
AU - Barch, Deanna M.
N1 - Funding Information:
This research was supported by NIH grants P50 MH071616 and R01 MH56584 . NIH had no further role in the current study with regard to data collection, data analysis and interpretation of findings or in manuscript preparation and the submission decision.
Funding Information:
Dr. Csernansky has received research grants from the NIMH and NIA, and royalties from Medtronic for a patent held jointly with Washington University School of Medicine, has been a paid consultant for Eli Lilly and Sanofi-Aventis, and has received speakers' honoraria from Janssen Pharmaceutica, Eli Lilly and Bristol-Myers Squibb. Dr. Deanna Barch has received grants from the NIMH, NIA, NARSAD and the McDonnel Center for Systems Neuroscience. None reported for the other authors.
PY - 2010/7
Y1 - 2010/7
N2 - Previous work has demonstrated less accurate alignment of cortical structures for patients with schizophrenia than for matched control subjects when using affine registration techniques. Such a mismatch presents a potential confound for functional neuroimaging studies conducting between-group comparisons. Critically, the same issues may be present for subcortical structures. However, to date no study has explicitly investigated alignment precision for major subcortical structures in patients with schizophrenia. Thus, to address this question we used methods previously validated for assessment of cortical alignment precision to examine alignment precision of subcortical structures. In contrasts to our results with cortex, we found that major subcortical structures (i.e. amygdala, caudate, hippocampus, pallidum, putamen and thalamus) showed similar alignment precision for schizophrenia (N=48) and control subjects (N=45) regardless of the template used (other individuals with schizophrenia or healthy controls). Taken together, the present results show that, unlike cortex, alignment for six major subcortical structures is not compromised in patients with schizophrenia and as such is unlikely to confound between-group functional neuroimaging investigations.
AB - Previous work has demonstrated less accurate alignment of cortical structures for patients with schizophrenia than for matched control subjects when using affine registration techniques. Such a mismatch presents a potential confound for functional neuroimaging studies conducting between-group comparisons. Critically, the same issues may be present for subcortical structures. However, to date no study has explicitly investigated alignment precision for major subcortical structures in patients with schizophrenia. Thus, to address this question we used methods previously validated for assessment of cortical alignment precision to examine alignment precision of subcortical structures. In contrasts to our results with cortex, we found that major subcortical structures (i.e. amygdala, caudate, hippocampus, pallidum, putamen and thalamus) showed similar alignment precision for schizophrenia (N=48) and control subjects (N=45) regardless of the template used (other individuals with schizophrenia or healthy controls). Taken together, the present results show that, unlike cortex, alignment for six major subcortical structures is not compromised in patients with schizophrenia and as such is unlikely to confound between-group functional neuroimaging investigations.
KW - Anatomical alignment
KW - Registration
KW - Schizophrenia
KW - Subcortex
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U2 - 10.1016/j.schres.2009.12.040
DO - 10.1016/j.schres.2009.12.040
M3 - Article
C2 - 20097545
AN - SCOPUS:77954144574
SN - 0920-9964
VL - 120
SP - 76
EP - 83
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
