Subcortical brain atrophy persists even in HAART-regulated HIV disease

James T. Becker, Joanne Sanders, Sarah K. Madsen, Ann Ragin, Lawrence Kingsley, Victoria Maruca, Bruce Cohen, Karl Goodkin, Eileen Martin, Eric N. Miller, Ned Sacktor, Jeffery R. Alger, Peter B. Barker, Priyanka Saharan, Owen T. Carmichael, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


The purpose of this study was to determine the pattern and extent of caudate nucleus and putamen atrophy in HIV-infected men with well-controlled immune status and viral replication. 155 men underwent structural brain magnetic resonance imaging; 84 were HIV-infected and 71 were uninfected controls. MRI data were processed using the Fully Deformable Segmentation routine, producing volumes for the right and left caudate nucleus and putamen, and 3-D maps of spatial patterns of thickness. There was significant atrophy in the HIV-infected men in both the caudate and putamen, principally in the anterior regions. The volume of the basal ganglia was inversely associated with the time since first seropositivity, suggesting that either there is a chronic, subclinical process that continues in spite of therapy, or that the extent of the initial insult caused the extent of atrophy.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalBrain Imaging and Behavior
Issue number2
StatePublished - Jun 2011


  • Basal ganglia
  • Gray matter
  • HIV
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Radiology Nuclear Medicine and imaging
  • Behavioral Neuroscience


Dive into the research topics of 'Subcortical brain atrophy persists even in HAART-regulated HIV disease'. Together they form a unique fingerprint.

Cite this