Subcutaneous administration of allergen vaccines

Michael Radtke, Leslie C. Grammer

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Subcutaneous allergen immunotherapy (SCIT) was first described in the United States by Noon and Freeman in 1911 (1) and has been used subsequently for the treatment of allergic symptoms due to inhalant allergens. In 1918, Dr. Robert Cooke suggested a mechanism of action for allergen injections as a “desensitization or hyposensitization.” Prausnitz and Kustner elucidated the more specific immunologic basis for allergic disease, demonstrating that allergic sensitivity could be transferred by the serum of a sensitive person to the skin of a nonallergic person (2). SCIT is defined as the repeated administration of specific allergens to patients with IgE-mediated conditions for the purpose of providing protection against the allergic symptoms and inflammatory reactions associated with natural exposure to these allergens (3). The technique of SCIT differs from the process of desensitization, the term applied to the rapid, progressive administration of an allergenic substance, usually a drug, to render effector cells less reactive.

Original languageEnglish (US)
Title of host publicationAllergens and Allergen Immunotherapy, Fourth Edition
PublisherCRC Press
Number of pages12
ISBN (Electronic)9781420061987
ISBN (Print)1420061976, 9781420061970
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Medicine(all)


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