TY - JOUR
T1 - Subcutaneous infiltration of carbon dioxide (carboxytherapy) for abdominal fat reduction
T2 - A randomized clinical trial
AU - Alam, Murad
AU - Sadhwani, Divya
AU - Geisler, Amelia
AU - Aslam, Imran
AU - Makin, Inder Raj S.
AU - Schlessinger, Daniel I.
AU - Disphanurat, Wareeporn
AU - Pongprutthipan, Marisa
AU - Voravutinon, Nataya
AU - Weil, Alexandra
AU - Chen, Brian R.
AU - West, Dennis P.
AU - Veledar, Emir
AU - Poon, Emily
N1 - Publisher Copyright:
© 2018 American Academy of Dermatology, Inc.
PY - 2018/8
Y1 - 2018/8
N2 - Background: Noninvasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new noninvasive fat removal treatments that are both safe and efficacious. Objective: To assess the extent to which carboxytherapy, which is the insufflation of carbon dioxide gas into subcutaneous fat, results in reduction of fat volume. Methods: In this randomized, sham-controlled, split-body study, adults (body mass index, 22-29 kg/m2) were randomized to receive 5 weekly infusions of 1000 cm3 of CO2 to 1 side of the abdomen, and 5 sham treatments to the contralateral side. The primary outcome measures were ultrasound measurement of fat layer thickness and total circumference before and after treatment. Results: A total of 16 participants completed the study. Ultrasound measurement indicated less fat volume on the side treated with carboxytherapy 1 week after the last treatment (P =.011), but the lower fat volume was not maintained at 28 weeks. Total circumference decreased nominally but not significantly at week 5 compared with baseline (P =.0697). Participant body weights did not change over the entire course of the study (P = 1.00). Limitations: Limitations included modest sample size and some sources of error in the measurement of circumference and fat layer. Conclusion: Carboxytherapy provides a transient decrease in subcutaneous fat that may not persist. Treatment is well tolerated.
AB - Background: Noninvasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new noninvasive fat removal treatments that are both safe and efficacious. Objective: To assess the extent to which carboxytherapy, which is the insufflation of carbon dioxide gas into subcutaneous fat, results in reduction of fat volume. Methods: In this randomized, sham-controlled, split-body study, adults (body mass index, 22-29 kg/m2) were randomized to receive 5 weekly infusions of 1000 cm3 of CO2 to 1 side of the abdomen, and 5 sham treatments to the contralateral side. The primary outcome measures were ultrasound measurement of fat layer thickness and total circumference before and after treatment. Results: A total of 16 participants completed the study. Ultrasound measurement indicated less fat volume on the side treated with carboxytherapy 1 week after the last treatment (P =.011), but the lower fat volume was not maintained at 28 weeks. Total circumference decreased nominally but not significantly at week 5 compared with baseline (P =.0697). Participant body weights did not change over the entire course of the study (P = 1.00). Limitations: Limitations included modest sample size and some sources of error in the measurement of circumference and fat layer. Conclusion: Carboxytherapy provides a transient decrease in subcutaneous fat that may not persist. Treatment is well tolerated.
KW - carboxytherapy
KW - fat reduction
KW - fat volume
KW - noninvasive fat reduction
KW - subcutaneous fat
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U2 - 10.1016/j.jaad.2018.04.038
DO - 10.1016/j.jaad.2018.04.038
M3 - Article
C2 - 29698710
AN - SCOPUS:85047951043
SN - 0190-9622
VL - 79
SP - 320
EP - 326
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -