TY - JOUR
T1 - Subendocardial motion in hypertrophic cardiomyopathy
T2 - Assessment from long- and short-axis views by pulsed tissue doppler imaging
AU - Tabata, Tomotsugu
AU - Oki, Takashi
AU - Yamada, Hirotsugu
AU - Abe, Miho
AU - Onose, Yukiko
AU - Thomas, James D.
N1 - Funding Information:
Supported in part by Grant NCC9-60, National Aeronautics and Space Administration, Houston, Tex.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000/2
Y1 - 2000/2
N2 - Background: Tissue Doppler imaging (TDI) is a recently developed technique that allows the instantaneous measurement of intrinsic regional myocardial motion velocity. Pulsed TDI is capable of separately assessing left ventricular (LV) regional motion velocity caused by circumferential and longitudinal fiber contraction. This particular feature of function is still controversial in patients with hypertrophic cardiomyopathy (HC). Methods: To better characterize intrinsic circumferential and longitudinal LV systolic myocardial function in HC, we used pulsed TDI to measure short- and long-axis LV motion velocities, respectively. The subendocardial motion velocity patterns at the middle of the LV posterior wall (PW) and ventricular septum (IVS) in LV parasternal and apical long-axis views were recorded by pulsed TDI in 19 patients with nonobstructive HC and in 21 normal controls (NC). Results: Peak short- and long-axis systolic subendocardial velocities in both the LV PW and IVS were significantly smaller in the HC group than in the NC group, and the time to peak velocity was significantly delayed. Furthermore, peak PW systolic velocity was significantly greater along the long axis than along the short axis in the NC group (8.8 ± 1.5 cm/s vs 8.2 ± 1.4 cm/s, P < .05), whereas the opposite was observed in the HC group (6.1 ± 1.2 cm/s vs 7.5 ± 1.0 cm/s, P < .0001). No significant differences were found in either group between the long- and short-axis IVS velocities (HC: 5.9 ± 1.4 cm/s vs 5.5 ± 1.3 cm/s; NC: 7.8 ± 1.3 cm/s vs 7.9 ± 1.6 cm/s). Conclusions: By using the capability of pulsed TDI for the evaluation of intrinsic myocardial velocity instantaneously in a specific region and direction, we found impairment of LV myocardial systolic function in patients with HC not only in the hypertrophied IVS but also in the nonhypertrophied LV PW. We also found a greater decrease in LV PW velocities along the long axis than the short axis, suggesting greater impairment of long-axis contraction in patients with HC. Because our HC patients did not appear to have excessive intracavitary pressure, these results suggest that the relatively normal-appearing PW is directly affected by the HC pathologic process.
AB - Background: Tissue Doppler imaging (TDI) is a recently developed technique that allows the instantaneous measurement of intrinsic regional myocardial motion velocity. Pulsed TDI is capable of separately assessing left ventricular (LV) regional motion velocity caused by circumferential and longitudinal fiber contraction. This particular feature of function is still controversial in patients with hypertrophic cardiomyopathy (HC). Methods: To better characterize intrinsic circumferential and longitudinal LV systolic myocardial function in HC, we used pulsed TDI to measure short- and long-axis LV motion velocities, respectively. The subendocardial motion velocity patterns at the middle of the LV posterior wall (PW) and ventricular septum (IVS) in LV parasternal and apical long-axis views were recorded by pulsed TDI in 19 patients with nonobstructive HC and in 21 normal controls (NC). Results: Peak short- and long-axis systolic subendocardial velocities in both the LV PW and IVS were significantly smaller in the HC group than in the NC group, and the time to peak velocity was significantly delayed. Furthermore, peak PW systolic velocity was significantly greater along the long axis than along the short axis in the NC group (8.8 ± 1.5 cm/s vs 8.2 ± 1.4 cm/s, P < .05), whereas the opposite was observed in the HC group (6.1 ± 1.2 cm/s vs 7.5 ± 1.0 cm/s, P < .0001). No significant differences were found in either group between the long- and short-axis IVS velocities (HC: 5.9 ± 1.4 cm/s vs 5.5 ± 1.3 cm/s; NC: 7.8 ± 1.3 cm/s vs 7.9 ± 1.6 cm/s). Conclusions: By using the capability of pulsed TDI for the evaluation of intrinsic myocardial velocity instantaneously in a specific region and direction, we found impairment of LV myocardial systolic function in patients with HC not only in the hypertrophied IVS but also in the nonhypertrophied LV PW. We also found a greater decrease in LV PW velocities along the long axis than the short axis, suggesting greater impairment of long-axis contraction in patients with HC. Because our HC patients did not appear to have excessive intracavitary pressure, these results suggest that the relatively normal-appearing PW is directly affected by the HC pathologic process.
UR - http://www.scopus.com/inward/record.url?scp=0033955724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033955724&partnerID=8YFLogxK
U2 - 10.1016/S0894-7317(00)90021-X
DO - 10.1016/S0894-7317(00)90021-X
M3 - Article
C2 - 10668013
AN - SCOPUS:0033955724
SN - 0894-7317
VL - 13
SP - 108
EP - 115
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 2
ER -