Subfornical organ: Duration of dipsogenic action of angiotensin-II

Joan Mitrius*, Aryeh Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Prior evidence from our laboratory has implicated the subfornical organ (SFO) as a site of angiotensin-II (A-II)-induced drinking [22]. In the present study, animals were denied access to water for 0, 0.5 and 1.0 h following a single intracranial A-II injection into the SFO. Even after a delay of 1.0 h, A-II-injected animals showed increased water consumption compared to controls. Animals injected with A-II and tested immediately consumed significantly more water than the 1 h delay animals. Potential mechanisms involved in the maintenance of the drinking effect of A-II after 1 h and the decreased drinking in 1.0 h relative to the 0 h group were considered.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalNeuroscience Letters
Issue number3-4
StatePublished - Jul 1977

ASJC Scopus subject areas

  • Neuroscience(all)


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