Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis

Alison Hsin-I Chang, Kirsten C Moisio, Joan S Chmiel, Felix Eckstein, Ali Guermazi, Orit Almagor, September Cahue, Wolfgang Wirth, Pottumarthi Prasad, Leena Sharma*

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives: Meniscal tears have been linked to knee osteoarthritis progression, presumably by impaired load attenuation. How meniscal tears affect osteoarthritis is unclear; subregional examination may help to elucidate whether the impact is local. This study examined the association between a tear within a specifi c meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies. Methods: Participants with knee osteoarthritis underwent bilateral knee MRI at baseline and 2 years. Mean cartilage thickness within each subregion was quantifi ed. Logistic regression with generalised estimating equations were used to analyse the relationship between baseline meniscal tear in each segment and baseline to 2-year cartilage loss in each subregion, adjusting for age, gender, body mass index, tear in the other two segments and extrusion. Results: 261 knees were studied in 159 individuals. Medial meniscal body tear was associated with cartilage loss in external subregions and in central and anterior tibial subregions, and posterior horn tear specifi cally with posterior tibial subregion loss; these relationships were independent of tears in the other segments and persisted in tibial subregions after adjustment for extrusion. Lateral meniscal body and posterior horn tear were also associated with cartilage loss in underlying subregions but not after adjustment for extrusion. Cartilage loss in the internal subregions, not covered by the menisci, was not associated with meniscal tear in any segment. Conclusion: These results suggest that the detrimental effect of meniscal tears is not spatially uniform across the tibial and femoral cartilage surfaces and that some of the effect is experienced locally.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number1
DOIs
StatePublished - Jan 1 2011

Fingerprint

Knee Osteoarthritis
Cartilage
Tears
Extrusion
Horns
Knee
Magnetic resonance imaging
Logistics
Thigh
Osteoarthritis
Body Mass Index
Logistic Models

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chang, Alison Hsin-I ; Moisio, Kirsten C ; Chmiel, Joan S ; Eckstein, Felix ; Guermazi, Ali ; Almagor, Orit ; Cahue, September ; Wirth, Wolfgang ; Prasad, Pottumarthi ; Sharma, Leena. / Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis. In: Annals of the Rheumatic Diseases. 2011 ; Vol. 70, No. 1. pp. 74-79.
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abstract = "Objectives: Meniscal tears have been linked to knee osteoarthritis progression, presumably by impaired load attenuation. How meniscal tears affect osteoarthritis is unclear; subregional examination may help to elucidate whether the impact is local. This study examined the association between a tear within a specifi c meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies. Methods: Participants with knee osteoarthritis underwent bilateral knee MRI at baseline and 2 years. Mean cartilage thickness within each subregion was quantifi ed. Logistic regression with generalised estimating equations were used to analyse the relationship between baseline meniscal tear in each segment and baseline to 2-year cartilage loss in each subregion, adjusting for age, gender, body mass index, tear in the other two segments and extrusion. Results: 261 knees were studied in 159 individuals. Medial meniscal body tear was associated with cartilage loss in external subregions and in central and anterior tibial subregions, and posterior horn tear specifi cally with posterior tibial subregion loss; these relationships were independent of tears in the other segments and persisted in tibial subregions after adjustment for extrusion. Lateral meniscal body and posterior horn tear were also associated with cartilage loss in underlying subregions but not after adjustment for extrusion. Cartilage loss in the internal subregions, not covered by the menisci, was not associated with meniscal tear in any segment. Conclusion: These results suggest that the detrimental effect of meniscal tears is not spatially uniform across the tibial and femoral cartilage surfaces and that some of the effect is experienced locally.",
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Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis. / Chang, Alison Hsin-I; Moisio, Kirsten C; Chmiel, Joan S; Eckstein, Felix; Guermazi, Ali; Almagor, Orit; Cahue, September; Wirth, Wolfgang; Prasad, Pottumarthi; Sharma, Leena.

In: Annals of the Rheumatic Diseases, Vol. 70, No. 1, 01.01.2011, p. 74-79.

Research output: Contribution to journalArticle

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T1 - Subregional effects of meniscal tears on cartilage loss over 2 years in knee osteoarthritis

AU - Chang, Alison Hsin-I

AU - Moisio, Kirsten C

AU - Chmiel, Joan S

AU - Eckstein, Felix

AU - Guermazi, Ali

AU - Almagor, Orit

AU - Cahue, September

AU - Wirth, Wolfgang

AU - Prasad, Pottumarthi

AU - Sharma, Leena

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objectives: Meniscal tears have been linked to knee osteoarthritis progression, presumably by impaired load attenuation. How meniscal tears affect osteoarthritis is unclear; subregional examination may help to elucidate whether the impact is local. This study examined the association between a tear within a specifi c meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies. Methods: Participants with knee osteoarthritis underwent bilateral knee MRI at baseline and 2 years. Mean cartilage thickness within each subregion was quantifi ed. Logistic regression with generalised estimating equations were used to analyse the relationship between baseline meniscal tear in each segment and baseline to 2-year cartilage loss in each subregion, adjusting for age, gender, body mass index, tear in the other two segments and extrusion. Results: 261 knees were studied in 159 individuals. Medial meniscal body tear was associated with cartilage loss in external subregions and in central and anterior tibial subregions, and posterior horn tear specifi cally with posterior tibial subregion loss; these relationships were independent of tears in the other segments and persisted in tibial subregions after adjustment for extrusion. Lateral meniscal body and posterior horn tear were also associated with cartilage loss in underlying subregions but not after adjustment for extrusion. Cartilage loss in the internal subregions, not covered by the menisci, was not associated with meniscal tear in any segment. Conclusion: These results suggest that the detrimental effect of meniscal tears is not spatially uniform across the tibial and femoral cartilage surfaces and that some of the effect is experienced locally.

AB - Objectives: Meniscal tears have been linked to knee osteoarthritis progression, presumably by impaired load attenuation. How meniscal tears affect osteoarthritis is unclear; subregional examination may help to elucidate whether the impact is local. This study examined the association between a tear within a specifi c meniscal segment and subsequent 2-year cartilage loss in subregions that the torn segment overlies. Methods: Participants with knee osteoarthritis underwent bilateral knee MRI at baseline and 2 years. Mean cartilage thickness within each subregion was quantifi ed. Logistic regression with generalised estimating equations were used to analyse the relationship between baseline meniscal tear in each segment and baseline to 2-year cartilage loss in each subregion, adjusting for age, gender, body mass index, tear in the other two segments and extrusion. Results: 261 knees were studied in 159 individuals. Medial meniscal body tear was associated with cartilage loss in external subregions and in central and anterior tibial subregions, and posterior horn tear specifi cally with posterior tibial subregion loss; these relationships were independent of tears in the other segments and persisted in tibial subregions after adjustment for extrusion. Lateral meniscal body and posterior horn tear were also associated with cartilage loss in underlying subregions but not after adjustment for extrusion. Cartilage loss in the internal subregions, not covered by the menisci, was not associated with meniscal tear in any segment. Conclusion: These results suggest that the detrimental effect of meniscal tears is not spatially uniform across the tibial and femoral cartilage surfaces and that some of the effect is experienced locally.

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