Subsets of ATP-sensitive potassium channel (K ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expression

Thomas M. Bodenstine; Kedar S. Vaidya; Aimen Ismail; Benjamin H. Beck; Anne R. Diers; Mick D. Edmonds; Gina T. Kirsammer; Aimee Landar; Danny R. Welch

doi:10.1016/j.febslet.2011.11.017

Subsets of ATP-sensitive potassium channel (K _ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expression

Thomas M. Bodenstine, Kedar S. Vaidya, Aimen Ismail, Benjamin H. Beck, Anne R. Diers, Mick D. Edmonds, Gina T. Kirsammer, Aimee Landar, Danny R. Welch^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. K _ATP channels help maintain membrane polarity and linkages between K _ATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple K _ATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of K _ATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds.

Original language	English (US)
Pages (from-to)	27-31
Number of pages	5
Journal	FEBS Letters
Volume	586
Issue number	1
DOIs	https://doi.org/10.1016/j.febslet.2011.11.017
State	Published - Jan 2 2012

Keywords

Gap junction
Glibenclamide
K
Sulfonylurea

ASJC Scopus subject areas

Genetics
Molecular Biology
Biophysics
Structural Biology
Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.febslet.2011.11.017

Cite this

Bodenstine, T. M., Vaidya, K. S., Ismail, A., Beck, B. H., Diers, A. R., Edmonds, M. D., Kirsammer, G. T., Landar, A., & Welch, D. R. (2012). Subsets of ATP-sensitive potassium channel (K _ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expression. FEBS Letters, 586(1), 27-31. https://doi.org/10.1016/j.febslet.2011.11.017

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abstract = "Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. K ATP channels help maintain membrane polarity and linkages between K ATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple K ATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of K ATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds.",

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note = "Funding Information: The authors thank Drs. Janet Price (University of Texas M. D. Anderson Cancer Center) for providing the MDA-MB-231 and -435 cell lines and Frank Meyskens for initially providing the C8161 cell line. We also gratefully acknowledge support from the following agencies: National Foundation for Cancer Research (DRW), National Institutes of Health RO1-CA134981 (DRW); RO1-CA87728-09 (DRW) and Susan G. Komen for the Cure SAC110037 (DRW). ",

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Bodenstine, TM, Vaidya, KS, Ismail, A, Beck, BH, Diers, AR, Edmonds, MD, Kirsammer, GT, Landar, A & Welch, DR 2012, 'Subsets of ATP-sensitive potassium channel (K _ATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of sur expression', FEBS Letters, vol. 586, no. 1, pp. 27-31. https://doi.org/10.1016/j.febslet.2011.11.017

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AU - Beck, Benjamin H.

AU - Diers, Anne R.

AU - Edmonds, Mick D.

AU - Kirsammer, Gina T.

AU - Landar, Aimee

AU - Welch, Danny R.

N1 - Funding Information: The authors thank Drs. Janet Price (University of Texas M. D. Anderson Cancer Center) for providing the MDA-MB-231 and -435 cell lines and Frank Meyskens for initially providing the C8161 cell line. We also gratefully acknowledge support from the following agencies: National Foundation for Cancer Research (DRW), National Institutes of Health RO1-CA134981 (DRW); RO1-CA87728-09 (DRW) and Susan G. Komen for the Cure SAC110037 (DRW).

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