Substance P and somatostatin regulate sympathetic noradrenergic function

John A. Kessler*, Joshua E. Adler, Ira B. Black

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Peptidergic-noradrenergic interactions were examined in explants of rat sympathetic superior cervical ganglia and in cultures of dissociated cells. The putative peptide transmitters substance P and somatostatin each increased the activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase after 1 week of exposure in culture. Maximal increases occurred at 10-7 molar for each peptide, and either increasing or decreasing the concentration reduced the effects. Similar increases in tyrosine hydroxylase were produced by a metabolically stable agonist of substance P, while a substance P antagonist prevented the effects of the agonist. The data suggest that the increased tyrosine hydroxylase activity was mediated by peptide interaction with specific substance P receptors and that peptides may modulate sympathetic catecholaminergic function.

Original languageEnglish (US)
Pages (from-to)1059-1061
Number of pages3
JournalScience
Volume221
Issue number4615
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • General

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