Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Christine McCary, Brian P. Tancowny, Adriana Catalli, Leslie C. Grammer, Kathleen E. Harris, Robert P. Schleimer, Marianna Kulka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of Neuroimmunology
Volume220
Issue number1-2
DOIs
StatePublished - Mar 30 2010

Funding

This work was funded by the Ernest S. Bazely Trust to Northwestern Memorial Hospital and Northwestern University, a grant from the Bryan and Christina Cressey Foundation and an interest section award from the American Academy of Allergy, Asthma and Immunology.

Keywords

  • Fcε receptor
  • IgE
  • Mast cells
  • Stress
  • Substance P

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells'. Together they form a unique fingerprint.

Cite this