Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Christine McCary, Brian P. Tancowny, Adriana Catalli, Leslie C. Grammer, Kathleen E. Harris, Robert P. Schleimer, Marianna Kulka*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalJournal of Neuroimmunology
Volume220
Issue number1-2
DOIs
StatePublished - Mar 30 2010

Keywords

  • Fcε receptor
  • IgE
  • Mast cells
  • Stress
  • Substance P

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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