Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Christine McCary; Brian P. Tancowny; Adriana Catalli; Leslie C. Grammer; Kathleen E. Harris; Robert P. Schleimer; Marianna Kulka

doi:10.1016/j.jneuroim.2009.12.006

Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Christine McCary, Brian P. Tancowny, Adriana Catalli, Leslie C. Grammer, Kathleen E. Harris, Robert P. Schleimer, Marianna Kulka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown

Original language	English (US)
Pages (from-to)	17-24
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	220
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2009.12.006
State	Published - Mar 30 2010

Keywords

Fcε receptor
IgE
Mast cells
Stress
Substance P

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2009.12.006

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title = "Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells",

abstract = "The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown",

keywords = "Fcε receptor, IgE, Mast cells, Stress, Substance P",

author = "Christine McCary and Tancowny, {Brian P.} and Adriana Catalli and Grammer, {Leslie C.} and Harris, {Kathleen E.} and Schleimer, {Robert P.} and Marianna Kulka",

note = "Funding Information: This work was funded by the Ernest S. Bazely Trust to Northwestern Memorial Hospital and Northwestern University, a grant from the Bryan and Christina Cressey Foundation and an interest section award from the American Academy of Allergy, Asthma and Immunology.",

year = "2010",

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language = "English (US)",

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AU - McCary, Christine

AU - Tancowny, Brian P.

AU - Catalli, Adriana

AU - Grammer, Leslie C.

AU - Harris, Kathleen E.

AU - Schleimer, Robert P.

AU - Kulka, Marianna

N1 - Funding Information: This work was funded by the Ernest S. Bazely Trust to Northwestern Memorial Hospital and Northwestern University, a grant from the Bryan and Christina Cressey Foundation and an interest section award from the American Academy of Allergy, Asthma and Immunology.

PY - 2010/3/30

Y1 - 2010/3/30

N2 - The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown

AB - The effect of the neuropeptide substance P (SP) on human mast cell (MC) phenotype is poorly understood. In this study, SP effects on human MC expression of the high affinity IgE receptor (FcεRI) were characterized. SP downregulated expression of FcεRI mRNA and protein by approximately 50% and in a concentration dependent manner, the effect was partially mediated by engagement of the neurokinin-1 receptor (NK1R) and resulted in reduced mast cell activation. Sensitization of MC with IgE prior to SP exposure protected MC from SP-mediated FcεRI downregulation. SP release may inhibit MC responses to allergens and these results may have implications in neuroinflammatiion and stress. Crown

KW - Fcε receptor

KW - IgE

KW - Mast cells

KW - Stress

KW - Substance P

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Substance P downregulates expression of the high affinity IgE receptor (FcεRI) by human mast cells

Abstract

Keywords

ASJC Scopus subject areas

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