Substance P excites globus pallidus neurons in vivo

Qiao Ling Cui, Wing Ho Yung, Yan Xue, Lei Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Substance P is a member of the neurokinin family. Previous studies have reported the existence of substance P and its high-affinity receptor, neurokinin-1 receptor, in globus pallidus. Employing in vivo extracellular recording combined with behavioural tests, the effects of substance P in globus pallidus of rats were studied. Micropressure ejection of the selective neurokinin-1 receptor agonist [Sar9,Met(O2)11] substance P increased the spontaneous firing rate of pallidal neurons in a concentration-dependent manner, with increases of 27.3% at 0.01, 33.4% at 0.03, 45.5% at 0.1, 38.4% at 0.3 and 36.4% at 1.0 mm. The selective neurokinin-1 receptor antagonist SR140333B prevented the excitatory effects induced by [Sar9,Met(O2)11] substance P. In behaving rats, we observed the postural effects of neurokinin-1 receptor activation in the globus pallidus. Consistent with electrophysiological results, unilateral microinjection of [Sar9,Met(O2)11] substance P (0.1 mm) led to a SR140333B-sensitive contralateral deflection in the presence of systemic haloperidol administration. Combining electrophysiological and behavioural findings, we concluded that substance P produces excitatory effects on globus pallidus neurons via neurokinin-1 receptors.

Original languageEnglish (US)
Pages (from-to)1853-1861
Number of pages9
JournalEuropean Journal of Neuroscience
Issue number7
StatePublished - Oct 2007
Externally publishedYes


  • Extracellular recording
  • Microinjection
  • Neurokinin
  • Rat
  • Single unit recording
  • SR140333B

ASJC Scopus subject areas

  • Neuroscience(all)


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