TY - JOUR
T1 - Substance P levels differ in sympathetic target organ terminals and ganglion perikarya
AU - Kessler, J. A.
AU - Bell, W. O.
AU - Black, I. B.
N1 - Funding Information:
This work was supported by NIH grants NS 10259 and HD 12108 and aided by grants from the National Foundation-March of Dimes and the Cerebral Palsy Association. J.A.K. is the recipient of Teacher Investigator Award NS 00351 and the George C. Cotzias Research Fellowship. I.B.B. is the recipient of the Irma T. Hirschl Career Scientist Award. We wish to thank Ms. Robyn Walsh and Ms. Bettye Mayer for excellent technical assistance.
PY - 1983/1/3
Y1 - 1983/1/3
N2 - Regulation of the putative neurotransmitter, substance P (SP), was examined in the rat iris and pineal, targets of the peptide-containing superior cervical sympathetic ganglion (SCG). Decentralization (denervation) of the SCG, which is known to increase ganglion SP7,8, did not alter the peptide in either target. Conversely, surgical or pharmacologic (6-hydroxydopamine) ablation of the SCG actually increased SP in both targets. Moreover, destruction of the trigeminal sensory innervation reduced iris SP to virtually blank levels. Finally, trigeminal ablation abolished the rise in iris SP subsequent to sympathetic destruction with 6-hydroxydopamine. Our observations suggest that sympathetic terminals in targets, in contrast to ganglion perikarya and processes, contain negligible quantities of SP. Consequently, SP may not be transported from ganglion to periphery, but may serve an intraganglionic function. Our studies also suggest that sympathetic terminals modulate sensory peptidergic innervation of the iris.
AB - Regulation of the putative neurotransmitter, substance P (SP), was examined in the rat iris and pineal, targets of the peptide-containing superior cervical sympathetic ganglion (SCG). Decentralization (denervation) of the SCG, which is known to increase ganglion SP7,8, did not alter the peptide in either target. Conversely, surgical or pharmacologic (6-hydroxydopamine) ablation of the SCG actually increased SP in both targets. Moreover, destruction of the trigeminal sensory innervation reduced iris SP to virtually blank levels. Finally, trigeminal ablation abolished the rise in iris SP subsequent to sympathetic destruction with 6-hydroxydopamine. Our observations suggest that sympathetic terminals in targets, in contrast to ganglion perikarya and processes, contain negligible quantities of SP. Consequently, SP may not be transported from ganglion to periphery, but may serve an intraganglionic function. Our studies also suggest that sympathetic terminals modulate sensory peptidergic innervation of the iris.
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U2 - 10.1016/0006-8993(83)91240-4
DO - 10.1016/0006-8993(83)91240-4
M3 - Article
AN - SCOPUS:0020665821
SN - 0006-8993
VL - 258
SP - 144
EP - 146
JO - Brain research
JF - Brain research
IS - 1
ER -