Substantia nigra 6‐hydroxydopamine lesions alter dopaminergic synaptic markers in the nucleus basalis magnocellularis and striatum of rats

Changiz Geula*, John T. Slevin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Recent findings have demonstrated the existence of dopaminergic (DA) markers in the nbM of the human brain and a reduction of these markers in both the nbM and the striatum of patients suffering from Alzheimer's disease (AD). To investigate the source of the DA synaptic markers found in the nbM, rats received unilateral 6‐OHDA lesions of the substantia nigra pars compacta (SNc). The SNc lesions caused signigificant reductions in DA and DOPAC but not HVA in the nbM and the striaum; 3H‐sulpiride binding to D2 receptors ipsilateral to the SNc lesion was significantly increased in the stratum (16%), consistent with denervation supersensitivity, but single‐point analysis showed no significant changes in the nbM. These data suggest that the decreases in DA and 3H‐spiperone binding levels observed in the nbM of AD patients may be due to partial destruction of DA nbM afferent projections from the brainstem.

Original languageEnglish (US)
Pages (from-to)248-253
Number of pages6
JournalSynapse
Volume4
Issue number3
DOIs
StatePublished - 1989

Keywords

  • Alzheimer's disease
  • Dopamine
  • Sulpiride binding

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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