Keratohyalin granules from both human and rat epidermis were studied by high resolution electron microscopy. At high magnification (× 250 000), the dense mass in keratohyalin granules revealed a fine granular substructure consisting of particles with dimensions in the range of 13-35 Å, with an average value of 20 Å. It was concluded that this particulate material represented a specific differentiation product of epidermal cells, primarily responsible for keratohyalin granule formation.
ASJC Scopus subject areas
- Molecular Biology