Subterminal motor nerve abnormalities in psychotic patients

H. Y. Meltzer*, J. W. Crayton

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


THERE is considerable evidence of neuromuscular dysfunction in most patients with all types of the functional psychoses. Examples of such dysfunction are (1) increased activity of skeletal-muscle-type creatine phosphokinase (CPK) in serum in the acute stage of psychosis1-4; (2) abnormally large increases in serum CPK activity with a standardised exercise test performed by patients in symptomatic remission5; (3) morphological abnormalities in skeletal muscle fibres at biopsy, particularly scattered atrophic fibres and extensive areas of Z-band streaming6-8; and (4) abnormalities of eye movements in tracking a pendulum9. The skeletal muscle fibre abnormalities found in psychotic patients are likely to be neurogenic in origin10.

Original languageEnglish (US)
Pages (from-to)373-375
Number of pages3
Issue number5455
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • General


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