THERE is considerable evidence of neuromuscular dysfunction in most patients with all types of the functional psychoses. Examples of such dysfunction are (1) increased activity of skeletal-muscle-type creatine phosphokinase (CPK) in serum in the acute stage of psychosis1-4; (2) abnormally large increases in serum CPK activity with a standardised exercise test performed by patients in symptomatic remission5; (3) morphological abnormalities in skeletal muscle fibres at biopsy, particularly scattered atrophic fibres and extensive areas of Z-band streaming6-8; and (4) abnormalities of eye movements in tracking a pendulum9. The skeletal muscle fibre abnormalities found in psychotic patients are likely to be neurogenic in origin10.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Dec 1 1974|
ASJC Scopus subject areas