@article{8620786f02f54988860f3c31c2b7efa8,
title = "Subthalamic nucleus-sensorimotor cortex functional connectivity in de novo and moderate Parkinson's disease",
abstract = "Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson's disease (PD) compared with control subjects. It is not clear if the increase in functional connectivity between STN and sensorimotor cortex occurs in de novo PD, which is before patients begin dopamine therapy. Resting-state functional magnetic resonance imaging was carried out in 20 de novo (drug na{\"i}ve) patients with PD (Hoehn and Yahr stage: I-II), 19 patients with moderate PD (Hoehn and Yahr stage: II-III), and 19 healthy controls. The functional connectivity analysis in de novo and moderate PD patients focused on the connectivity of the more affected STN and the sensorimotor cortex. Using resting-state functional connectivity analysis, we provide new evidence that people with de novo PD and off-medicated moderate PD have increased functional connectivity between the more affected STN and different regions within the sensorimotor cortex. The overlapping sensorimotor cortex found in both de novo and moderate PD had functional connectivity values that correlated positively with the Unified Parkinson's Disease Rating Scale part III. This key finding suggests that changes in functional connectivity between STN and sensorimotor cortex occur early in the disease following diagnosis and before dopamine therapy.",
keywords = "Connectivity, Drug naive, Parkinson's disease, Subthalamic nucleus",
author = "Kurani, {Ajay S.} and Seidler, {Rachael D.} and Burciu, {Roxana G.} and Comella, {Cynthia L.} and Corcos, {Daniel M.} and Okun, {Michael S.} and MacKinnon, {Colum D.} and Vaillancourt, {David E.}",
note = "Funding Information: This work was supported by National Institute of Neurological Disorders and Stroke R01 NS052318 and R01 NS075012 and a grant from the Michael J. Fox Foundation for Parkinson's Research . The authors thank the patients and the healthy controls for their time and commitment to this research. Funding Information: Ajay Kurani has no conflicts of interest to report. Dr Rachael Seidler receives grant support from NASA and is a consultant for the University of Florida. Dr Roxana Burciu has no conflicts of interest to report. Dr Cynthia Comella receives research support from Allergan, Dystonia Coalition, Dystonia Medical Research Foundation, Ipsen Limited, Merz Pharmaceuticals, NIH, and Parkinson Disease Foundation. She receives compensation and/or honoraria for services as a consultant or an advisory committee member for Allergan, Impax Pharmaceuticals, Ipsen Biopharmaceuticals, Medtronic Inc, Merz Pharmaceuticals, US World Meds, and Teva Neurosciences. She receives royalties from Cambridge, Humana Press, and Wolters Kluwer. Dr Daniel Corcos receives grant support from NIH, and receives lecture and reviewer fees from NIH. Dr Michael Okun serves as a consultant for the National Parkinson Foundation and has received research grants from NIH, NPF, the Michael J. Fox Foundation, the Parkinson Alliance, Smallwood Foundation, the Bachmann-Strauss Foundation, and the UF Foundation. Dr Okun has previously received honoraria but in the past >36 months has received no support from industry including travel. Dr Okun has received royalties for publications with Demos, Manson, Amazon, Smashwords, and Cambridge (movement disorders books). Dr Okun has participated in CME activities on movement disorders sponsored by the USF CME office, PeerView, Prime, and Vanderbilt University. The institution and not Dr Okun receives grants from Medtronic and ANS/St. Jude, and the PI has no financial interest in these grants. Dr Okun has participated as a site PI and/or co-I for several NIH, foundation, and industry sponsored trials over the years but has not received honoraria. Dr Colum Mackinnon receives grant support from NIH. Dr David Vaillancourt receives grant support from NIH, Bachmann-Strauss Foundation, and consults for projects at UT Southwestern Medical Center, University of Illinois at Chicago, and Great Lakes NeuroTechnologies. He is a co-founder of Neuroimaging Solutions, LLC. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.neurobiolaging.2014.07.004",
language = "English (US)",
volume = "36",
pages = "462--469",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "1",
}