Subunit composition of kainate receptors in hippocampal interneurons

Christophe Mulle*, Andreas Sailer, Geoffrey T. Swanson, Corinne Brana, Stephen O'Gorman, Bernhard Bettler, Stephen F. Heinemann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


Kainate receptor activation affects GABAergic inhibition in the hippocampus by mechanisms that are thought to involve the GluR5 subunit. We report that disruption of the GluR5 subunit gene does not cause the loss of functional KARs in CA1 interneurons, nor does it prevent kainate-induced inhibition of evoked GABAergic synaptic transmission onto CA1 pyramidal cells. However, KAR function is abolished in mice lacking both GluR5 and GluR6 subunits, indicating that KARs in CA1 stratum radiatum interneurons are heteromeric receptors composed of both subunits. In addition, we show the presence of presynaptic KARs comprising the GluR6 but not the GluR5 subunit that modulate synaptic transmission between inhibitory interneurons. The existence of two separate populations of KARs in hippocampal interneurons adds to the complexity of KAR localization and function.

Original languageEnglish (US)
Pages (from-to)475-484
Number of pages10
Issue number2
StatePublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)


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