Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection

Edwin C. McGee; William Cotts; Anat R. Tambur; John Friedewald; John Kim; John O'Connell; Suzanne Wallace; Patrick M. McCarthy

doi:10.1016/j.healun.2008.02.006

Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection

Edwin C. McGee, William Cotts, Anat R. Tambur, John Friedewald, John Kim, John O'Connell, Suzanne Wallace, Patrick M. McCarthy

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A 32-year-old man with doxorubicin-induced cardiomyopathy presented in cardiogenic shock. He underwent placement of a Novacor (WorldHeart, Inc., Oakland, CA) left ventricular assist device as a bridge to transplant. Post-operatively he developed a pump pocket infection and dehiscence of his abdominal wound with exposure of the pump. This was treated with irrigation and drainage, antibiotic bead placement and flap closure. Both pre- and post-operative panel-reactive antibodies (PRA) were elevated. He underwent desensitization with intravenous immune globulin (IVIg), rituximab, mycophenolate mofetil and pre-operative plasmapheresis. A donor heart was identified and found to be acceptable by virtual crossmatch. He was transplanted and is doing well with normal graft function at >1 year post-operatively.

Original language	English (US)
Pages (from-to)	568-571
Number of pages	4
Journal	Journal of Heart and Lung Transplantation
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.healun.2008.02.006
State	Published - May 2008

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Transplantation
Pulmonary and Respiratory Medicine
Surgery

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10.1016/j.healun.2008.02.006

Cite this

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title = "Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection",

abstract = "A 32-year-old man with doxorubicin-induced cardiomyopathy presented in cardiogenic shock. He underwent placement of a Novacor (WorldHeart, Inc., Oakland, CA) left ventricular assist device as a bridge to transplant. Post-operatively he developed a pump pocket infection and dehiscence of his abdominal wound with exposure of the pump. This was treated with irrigation and drainage, antibiotic bead placement and flap closure. Both pre- and post-operative panel-reactive antibodies (PRA) were elevated. He underwent desensitization with intravenous immune globulin (IVIg), rituximab, mycophenolate mofetil and pre-operative plasmapheresis. A donor heart was identified and found to be acceptable by virtual crossmatch. He was transplanted and is doing well with normal graft function at >1 year post-operatively.",

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T1 - Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection

AU - McGee, Edwin C.

AU - Cotts, William

AU - Tambur, Anat R.

AU - Friedewald, John

AU - Kim, John

AU - O'Connell, John

AU - Wallace, Suzanne

AU - McCarthy, Patrick M.

PY - 2008/5

Y1 - 2008/5

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AB - A 32-year-old man with doxorubicin-induced cardiomyopathy presented in cardiogenic shock. He underwent placement of a Novacor (WorldHeart, Inc., Oakland, CA) left ventricular assist device as a bridge to transplant. Post-operatively he developed a pump pocket infection and dehiscence of his abdominal wound with exposure of the pump. This was treated with irrigation and drainage, antibiotic bead placement and flap closure. Both pre- and post-operative panel-reactive antibodies (PRA) were elevated. He underwent desensitization with intravenous immune globulin (IVIg), rituximab, mycophenolate mofetil and pre-operative plasmapheresis. A donor heart was identified and found to be acceptable by virtual crossmatch. He was transplanted and is doing well with normal graft function at >1 year post-operatively.

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Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection

Abstract

ASJC Scopus subject areas

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