Successful Bridge to Transplant in a Highly Sensitized Patient With a Complicated Pump Pocket Infection

Edwin C. McGee, William Cotts, Anat R. Tambur, John Friedewald, John Kim, John O'Connell, Suzanne Wallace, Patrick M. McCarthy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A 32-year-old man with doxorubicin-induced cardiomyopathy presented in cardiogenic shock. He underwent placement of a Novacor (WorldHeart, Inc., Oakland, CA) left ventricular assist device as a bridge to transplant. Post-operatively he developed a pump pocket infection and dehiscence of his abdominal wound with exposure of the pump. This was treated with irrigation and drainage, antibiotic bead placement and flap closure. Both pre- and post-operative panel-reactive antibodies (PRA) were elevated. He underwent desensitization with intravenous immune globulin (IVIg), rituximab, mycophenolate mofetil and pre-operative plasmapheresis. A donor heart was identified and found to be acceptable by virtual crossmatch. He was transplanted and is doing well with normal graft function at >1 year post-operatively.

Original languageEnglish (US)
Pages (from-to)568-571
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number5
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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