Abstract
We report a case of a patient with end-stage liver disease secondary to hepatitis C, complicated by a large hepatocellular carcinoma. Because of the size of the tumor exceeded the Milan criteria, he was not a candidate for liver transplantation. However, after two treatments with yttrium-90 glass microsphere infusions, the tumor became smaller and the patient's α-fetoprotein level dropped to normal range. He was listed for transplantation and subsequently received a deceased donor liver transplant. Two years after his transplantation, he remains tumor free and has normal α-fetoprotein levels. This is the first reported case in the literature of using yttrium-90 microspheres as a bridge to liver transplantation in a patient with a large hepatocellular carcinoma. This therapy should be considered in patients with cirrhosis and large hepatocellular carcinomas exceeding current size criterion, who would otherwise be good candidates for transplantation.
Original language | English (US) |
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Pages (from-to) | 413-416 |
Number of pages | 4 |
Journal | Journal of Gastrointestinal Surgery |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2006 |
Keywords
- Brachytherapy
- Carcinoma
- Hepatocellular
- Liver
- Transplantation
- Yttrium
ASJC Scopus subject areas
- Surgery
- Gastroenterology