Successful embolization of hepatocelluar carcinoma with yttrium-90 glass microspheres prior to liver transplantation

Dean Y. Kim*, David S. Kwon, Riad Salem, Chan K. Ma, Marwan S. Abouljoud

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We report a case of a patient with end-stage liver disease secondary to hepatitis C, complicated by a large hepatocellular carcinoma. Because of the size of the tumor exceeded the Milan criteria, he was not a candidate for liver transplantation. However, after two treatments with yttrium-90 glass microsphere infusions, the tumor became smaller and the patient's α-fetoprotein level dropped to normal range. He was listed for transplantation and subsequently received a deceased donor liver transplant. Two years after his transplantation, he remains tumor free and has normal α-fetoprotein levels. This is the first reported case in the literature of using yttrium-90 microspheres as a bridge to liver transplantation in a patient with a large hepatocellular carcinoma. This therapy should be considered in patients with cirrhosis and large hepatocellular carcinomas exceeding current size criterion, who would otherwise be good candidates for transplantation.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalJournal of Gastrointestinal Surgery
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2006

Keywords

  • Brachytherapy
  • Carcinoma
  • Hepatocellular
  • Liver
  • Transplantation
  • Yttrium

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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